Evaluating A Diagnostic Test for Dementia with Lewy Bodies, the Syn-D Study

The Syn-D Study is a research study that aims to distinguish dementia with Lewy bodies (DLB) from Alzheimer’s disease in people at the early stages. This study may help advance early diagnosis of DLB.

What is this study about?

Researchers will evaluate a skin biopsy test that measures a protein that is implicated in DLB, called phosphorylated alpha-synuclein (P-SYN), which can be found in nerve fibers. The purpose is to assess whether the test distinguishes early DLB from early Alzheimer’s disease, and whether the test can provide valuable information about severity and progression of DLB.

What’s involved?

Participants will have two study visits over approximately one year. Each of these visits will include questions about the participant’s medical history, a neurological exam, and questionnaires. A medical professional will also take three small skin samples.

Participants will be paid $100 per completed visit.

Participants who wish to receive their test results may do so. Results are expected within six weeks of testing.

Who can participate?

You may be eligible to participate if you are:

  • Between the ages of 50 and 85
  • Have early-stage dementia with Lewy bodies or early-stage Alzheimer’s disease

You may not be eligible to participate if you:

  • Have heart disease
  • Have had a stroke
  • Use certain blood thinners
  • Have a history of scarring or keloid formation

Study Sites:

State City Study Site Name Study Contact Email and Phone Number
Arizona Scottsdale CND Life Sciences Aracely Galarza & Jade Stohl 480-569-2902
California San Diego University of California San Diego Marie-Laure Gollier magollier@health.ucsd.edu
Colorado Englewood (Denver area) CenExel RMCR Alyssa Andreen a.andreen@cenexel.com
Florida  Boca Raton University of Miami Comprehensive Center for Brain Health Shanell Disla sxd1210@med.miami.edu
Florida Winter Park (Orlando area) N1 Research Center Jennifer Morgera  admin@neurologyone.net
Louisiana New Orleans Ochsner Research Anna Leonard anna.leonard@ochsner.org
Massachusetts Boston Beth Israel Deaconess Medical Center Sarrah Marcotte sjmarcot@bidmc.harvard.edu
Massachusetts Boston Massachusetts General Erin Peterec epeterec@mgh.harvard.edu
Massachusetts Plymouth Practice of Donald S. Marks, MD, PC Erin Kearney erink@dsmmdpc.com
Tennessee Nashville Vanderbilt University Medical Center Haley Komorowski 615-875-9890
Utah Salt Lake City University of Utah Kendra Fowler kendra.fowler@utah.edu

Study Sponsor:

CND Life Sciences

Major funding for this study is provided by the U.S. National Institutes of Health (NIH).

To Find Other Studies:

Click here to see LBD studies that are currently seeking participants.

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