Study to Evaluate the Safety, Tolerability and Efficacy of CT1812 in Subjects With Mild to Moderate Dementia With Lewy Bodies (SHIMMER)

Dementia with Lewy bodies (DLB) is a progressive disorder affecting thinking, movement, behavior and sleep. Because currently there are no FDA-approved treatments for DLB, developing safe and effective treatments is the #1 priority for DLB research.

What is this study about?

The purpose of this clinical trial is to learn about the safety of CT1812 and how well it is tolerated. The study will also test how well CT1812 will treat mild to moderate DLB.

What’s involved?

Study participants will attend 12 study visits over 8 months. During that time, participants will be randomly assigned to take the study drug or a placebo (a pill with no active ingredients) for six months.

Who can participate?

You may be able to participate if you are:

  • Between the ages of 50 to 85
  • Have been diagnosed with mild to moderate dementia with Lewy bodies (DLB)
  • Have a caregiver/study partner who is willing and able to attend all study visits and participate in some study assessments

Study Sites:

State City Study Site Name Study Coordinator Email and Phone Number
Arizona Phoenix Barrow Neurological Institute Jalisa Santiago 800-392-2222
Arizona Sun City Banner Sun Health Research Institute Michele Gutierrez
Arizona Tucson University of Arizona – Health Sciences Center Scott Silviu Richards
California Fountain Valley The Parkinson’s and Movement Disorder Institute Evan Moreno-Davis
California Palo Alto Stanford University Stephanie Tran
California Santa Monica Pacific Neuroscience Institute Marisol Savage
Colorado Aurora University of Colorado Franklin Roberts, BS
Lauren McCall
Colorado Englewood Cenexel RMCR Beth Capozzi
Connecticut Stamford New England Institute for Clinical Research Katie Nejati
Florida Boca Raton University of Miami Adolfo M. Henriquez
Florida Boca Raton Parkinson’s Disease and Movement Disorders Center of Boca Raton
561-392-1818 ext 2
Florida Lady Lake Charter Research Omar Cortes
Florida Ocala Renstar Medical Research Alyssa Ashley
Florida Winter Park Charter Research Winter Park Jessica Garaycoa
Indiana Indianpolis JWM Neurology, P.C. Tammy Root
Kansas Fairway The University of Kansas Alzheimer’s Disease Research Center Alexandria Montero
Main Center: 913-588-0555
Ally direct: 913-574-2512
Kentucky Lexington University of Kentucky – Sanders Brown Center on Aging Keisha Jones
Minnesota Rochester Mayo Clinic Elizabeth Abrahamson
New York New York Columbia University Katrina Cuasay
North Carolina Chapel Hill UNC Department of Neurology Latorius Adams
Ohio Columbus The Ohio State University Emily Shalosky
Oregon Portland Oregon Health and Science University Morgan Wilhelmi
Texas Dallas University of Texas Southwestern Tiffani Fox
Virginia Charlottesville University of Virginia Adult Neurology Colleen Webber, CCRC
Virginia Richmond Virginia Commonwealth University Heather Ward
Washington Kirkland EvergreenHealth Research
Washington Seattle University of Washington Aasiya Islam

Study Sponsor:

Cognition Therapeutics

This study was funded by the National Institute on Aging, National Institutes of Health