Dementia with Lewy bodies (DLB) is a progressive disorder affecting thinking, movement, behavior and sleep. Because currently there are no FDA-approved treatments for DLB, developing safe and effective treatments is the #1 priority for DLB research.
What is this study about?
The purpose of this clinical trial is to learn about the safety of CT1812 and how well it is tolerated. The study will also test how well CT1812 will treat mild to moderate DLB.
What’s involved?
Study participants will attend 12 study visits over 8 months. During that time, participants will be randomly assigned to take the study drug or a placebo (a pill with no active ingredients) for six months.
Who can participate?
You may be able to participate if you are:
- Between the ages of 50 to 85
- Have been diagnosed with mild to moderate dementia with Lewy bodies (DLB)
- Have a caregiver/study partner who is willing and able to attend all study visits and participate in some study assessments
Study Sites:
| State | City | Study Site Name | Study Coordinator | Email and Phone Number |
| Arizona | Phoenix | Barrow Neurological Institute | Jalisa Santiago | 800-392-2222 |
| Arizona | Sun City | Banner Sun Health Research Institute | Michele Gutierrez | BSHRI.info@bannerhealth.com 623-832-6573 |
| Arizona | Tucson | University of Arizona – Health Sciences Center | Scott Silviu Richards | scottrichards@arizona.edu 520-626-3576 |
| California | Fountain Valley | The Parkinson’s and Movement Disorder Institute | Evan Moreno-Davis | evan@pmdi.org 714-378-5021 |
| California | Palo Alto | Stanford University | Stephanie Tran | trans@stanford.edu 650-521-7287 |
| California | Santa Monica | Pacific Neuroscience Institute | Marisol Savage | PNIFClinicalTrials@pacificneuro.org |
| Colorado | Aurora | University of Colorado | Franklin Roberts, BS Lauren McCall |
neuroresearch@cuanschutz.edu 303-724-4644 lauren.mccall@cuanschutz.edu 303-724-3624 |
| Colorado | Englewood | Cenexel RMCR | Beth Capozzi | b.capozzi@cenexel.com 303-867-5468 |
| Connecticut | Stamford | New England Institute for Clinical Research | Katie Nejati | Katie@neinh.com 203-914-1903 |
| Florida | Boca Raton | University of Miami | Adolfo M. Henriquez | amh122@med.miami.edu 561-869-6820 |
| Florida | Boca Raton | Parkinson’s Disease and Movement Disorders Center of Boca Raton | info@parkinsonscenter.org 561-392-1818 ext 2 |
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| Florida | Lady Lake | Charter Research | Omar Cortes | omar.cortes@charterresearch.com essie.luttrell@charterresearch.com 352-775-1000 |
| Florida | Ocala | Renstar Medical Research | Alyssa Ashley | alyssa.ashley@renstar.net 352-629-5800 |
| Florida | Winter Park | Charter Research Winter Park | Jessica Garaycoa | jessica.garaycoa@charterresearch.com 407-337-1000 |
| Indiana | Indianpolis | JWM Neurology, P.C. | Tammy Root | research@jwmneuro.com 317-537-6060 |
| Kansas | Fairway | The University of Kansas Alzheimer’s Disease Research Center | Alexandria Montero | amontero@kumc.edu Main Center: 913-588-0555 Ally direct: 913-574-2512 |
| Kentucky | Lexington | University of Kentucky – Sanders Brown Center on Aging | Keisha Jones | kcl.jones@uky.edu 859-323-1331 |
| Minnesota | Rochester | Mayo Clinic | Elizabeth Abrahamson | abrahamson.elizabeth@mayo.edu |
| New York | New York | Columbia University | Katrina Cuasay | kc2305@cumc.columbia.edu 212-305-2077 |
| North Carolina | Chapel Hill | UNC Department of Neurology | Latorius Adams | adamsl@neurology.unc.edu 919-962-2900 |
| Ohio | Columbus | The Ohio State University | Emily Shalosky | emily.shalosky@osumc.edu 614-293-5183 |
| Oregon | Portland | Oregon Health and Science University | Morgan Wilhelmi | wilhelmo@ohsu.edu 503-494-7235 |
| Texas | Dallas | University of Texas Southwestern | Tiffani Fox | Tiffani.Fox2@UTSouthwestern.edu 214-648-5797 |
| Virginia | Charlottesville | University of Virginia Adult Neurology | Colleen Webber, CCRC | Heather.ward@vcuhealth.org |
| Virginia | Richmond | Virginia Commonwealth University | Heather Ward | cmn6x@virginia.edu 434-243-5898 |
| Washington | Kirkland | EvergreenHealth Research | evergreenresearch@evergreenhealthcare.org 425-899-5385 |
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| Washington | Seattle | University of Washington | Aasiya Islam | aislam1@uw.edu 206-744-1822 |
Study Sponsor:
Cognition Therapeutics
This study was funded by the National Institute on Aging, National Institutes of Health