LBDA Research Centers of Excellence span a growing, nationwide network of top scientific facilities working to defeat LBD.
LBDA Research Centers of Excellence
See how some of the nation’s leading research and clinical care institutions are joining the LBDA in the fight against LBD.
Help advance LBD research. Opportunities to participate are on the rise across the country. Find a study near you.
Stay up-to-date on research news. Read our easy-to-understand summaries on important LBD research, as well as articles that highlight cutting-edge advances in diagnosis and clinical care.
Participate in Research
Learn about the different types of clinical research being conducted and find tools to help you decide if a clinical trial may be right for you.
Is a Precision Medicine Approach the Key to Successful Dementia Clinical Trials?
Precision medicine is an emerging approach to providing medical care to individuals based on their unique genetic, environmental or lifestyle factors. A new atopsy study from investigators at University of Pennsylvania suggests that finding safe and effective treatments for dementia may require a precision medicine approach.
Lewy and Lumbar Punctures
A lumbar puncture, also called spinal tap, is a low-risk medical procedure that can be done in a doctor’s office. Learn why spinal fluid is so important in LBD clinical research studies.
Warning Signs: Who Progresses from REM Sleep Behavior to Lewy Body Disorders?
An unusual sleep disorder that makes people physically act out their dreams, called REM sleep disorder or RBD, is a known risk factor for LBD, Parkinson’s disease and multiple system atrophy. New research has identified additional symptoms that, when paired with RBD, suggest a Lewy body disorder is underway. Read more about it on the Neurology Advisor
Scientific Advance: Diagnosing LBD in Living Persons
Using a procedure called a lumbar puncture (or spinal tap), researchers can now diagnose two Lewy body disorders with a high degree of accuracy — dementia with Lewy bodies and Parkinson’s disease. While very encouraging, more research is needed to know if the test results during life will match brain autopsy results.
Epilepsy Treatment Shows Promise in DLB
Researchers in Japan published promising data on a Phase II clinical trial on an existing seizure medication in people with dementia with Lewy bodies. When used as an add-on treatment to levodopa, zonisamide improved motor symptoms in DLB without worsening psychiatric symptoms, a common side-effect in DLB. These findings require replication in a larger series of patients (i.e. Phase III trial), but suggest this medication may be potentially useful in a subset of DLB patients with motor symptoms that are less responsive to standard levodopa treatment
Research Advance: DLB Genetics Uniquely Different from Parkinson's
The first large-scale genome-wide association study was recently completed in people with dementia with Lewy bodies, hinting at unique genetic differences between DLB, Alzheimer's disease, and Parkinson's disease. The findings confirmed previously reported associations of variations in three genes that increase the risk of a person developing DLB. Those genes are APOE, SNCA and GBA. A new gene, CNTN1, was also identified as one that may increase risk of DLB.
Could a Skin Biopsy Diagnose LBD?
New research suggests skin biopsies may hold strong potential to help diagnose dementia with Lewy bodies (DLB).
Warning signs of LBD identified during mild cognitive impairment stage
Microscopic protein deposits, called Lewy bodies, are present in the brain long before a person has enough symptoms to be diagnosed with Lewy body dementia (LBD). A new study identifies symptoms closely associated with LBD before a person has dementia — during the mild cognitive impairment stage.
New Diagnostic Criteria Published for DLB
New criteria for diagnosing dementia with Lewy bodies now allows clinicians to combine both clinical symptoms with biomarker test results. This provides healthcare professionals greater flexibility for diagnosis of a disorder which presents in a variety of ways.
LBD Duration Shortens with Co-existing Alzheimer’s Disease
The rate of progression in Lewy body dementia (LBD) is hard to predict at the time of diagnosis. New research indicates the presence of a second neurodegenerative disease process, Alzheimer’s disease (AD), has an impact on one’s prognosis.
Symptoms Differ in Alzheimer's when Lewy Bodies are Present
Lewy body pathology is found in up to 50% of cases of late-onset Alzheimer’s disease, which can make it challenging for physicians to distinguish the underlying cause or causes of dementia symptoms. The diagnostic problem is compounded because Lewy bodies alone can result in Lewy body dementia. A new study shines new light on important clinical differences between people who have autopsy-verified Alzheimer’s disease pathology alone versus those who have both Alzheimer’s and Lewy bodies.