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 Helicobacter pylori (stomach ulcer bacteria) 
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Joined: Thu Mar 05, 2009 11:03 am
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Post Helicobacter pylori (stomach ulcer bacteria)
This article is about Alzheimer's disease research. I'm posting it here just in case someone here can benefit from it.

What caught my attention is this statement: "At the 2-year clinical endpoint, cognitive and functional status parameters improved in the subgroup of patients where Hp eradication was successful ..., but not in the other patients. Hp eradication may positively influence AD manifestations, suggesting a possible common link between Hp and AD."

If you multiply 88% by 84.8%, you get ~75% Three out of four ain't bad.

Of course, other bacteria may be wiped out by the antibiotics. I have to wonder if some day they will discover that the culprit is some other bug, not the H-pylori.

"Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer’s disease"
Abstract Infectious agents have been proposed as potential causes of Alzheimer’s disease (AD). Recently, we documented a high prevalence of Helicobacter pylori (Hp) infection in patients with AD. We aim to access the effect of Hp eradication on the AD cognitive (MMSE: Mini Mental State Examination and CAMCOG: Cambridge Cognitive Examination for the Elderly) and functional (FRSSD: Functional Rating Scale for Symptoms of Dementia) status parameters. In the first part of the study, a total of 50 consecutive patients with AD and 30 age-matched anaemic controls underwent an upper gastrointestinal endoscopy, and gastric mucosal biopsies were obtained to detect the presence of Hp infection by histologic analysis and rapid urease test. Serum anti-Hp-specific IgG level was analysed by enzyme-linked immunosorbent assay. In the second part, Hp-positive AD patients received a triple eradication regimen (omeprazole, clarithromycin and amoxicillin), and all patients were followed up for 2 years, while under the same treatment with cholinesterase inhibitors. Hp was detected in 88% of AD patients and in 46.7% of controls (P < 0.001). Hp eradication was successful in 84.8% of treated patients. At the 2-year clinical endpoint, cognitive and functional status parameters improved in the subgroup of patients where Hp eradication was successful (P < 0.001 and P = 0.049 for MMSE and CAMCOG, respectively; P < 0.001 for FRSSD), but not in the other patients. Hp eradication may positively influence AD manifestations, suggesting a possible common link between Hp and AD.
http://www.springerlink.com/content/831 ... cd1e6&pi=2

A good follow-up question would be, how prevalent is an Hp infection?

"H. pylori gastritis produces no symptoms in 90 percent of infected persons. The prevalence of H. pylori infection varies geographically and has been demonstrated to be as high as 52 percent in the United States. Factors associated with higher infection rates are increasing age, African-American or Hispanic race, lower levels of education, and birth in a developing country."
http://www.aafp.org/afp/20020401/1327.html

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Thu Jun 18, 2009 4:12 pm
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