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 Namenda may help RBD in DLB and PDD 
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Post Namenda may help RBD in DLB and PDD
The Europeans (and especially the Swedes) have been doing lots of studies of memantine (Namenda) in DLB and PDD. The study discussed below looks at whether Namenda is helping in sleep disturbances -- excessive daytime sleepiness (EDS) and RBD (REM sleep behavior disorder). Study participants were given 20mg/day of Namenda or a placebo for 24 weeks. Results were that Namenda decreased probable RBD activity but had no effect on EDS.

International Journal of Geriatric Psychiatry. 2010 Oct;25(10):1030-1038.

The effect of memantine on sleep behaviour in dementia with Lewy bodies and Parkinson's disease dementia.

Larsson V, Aarsland D, Ballard C, Minthon L, Londos E.
Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Sweden.

OBJECTIVE: Two common and characteristic sleep disturbances have been described in dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD); excessive daytime sleepiness and REM sleep behaviour disorder (RBD). This study is an analysis of a secondary outcome measure of a larger study already reported, aimed to determine whether memantine has an effect on the sleep disturbances in DLB and PDD patients.

METHODS: Patients with DLB or PDD were included in a placebo-controlled, randomised controlled study of memantine (20?mg per day) for 24 weeks. The Stavanger Sleep Questionnaire and the Epworth Sleepiness Scale were used to evaluate the effect on sleep disturbances.

RESULTS: Forty two patients started treatment; 20 with memantine and 22 with placebo. The primary analysis was the comparison of change between the two groups during a 24-week period, using the modified ITT population (last observation carried forward). At 24 weeks, patients treated with memantine were less physically active during sleep while patients in the placebo group worsened. Mean difference between the groups (0.5 [0.05-0.90]) was significant (p=0.006). No significant change was observed in severity of excessive daytime sleepiness.

CONCLUSIONS: Memantine decreases probable REM sleep behaviour disorder in patients with DLB and PDD. Both diagnostic groups contributed equally to the outcome.

Copyright © 2010 John Wiley & Sons, Ltd.

PubMed ID#: 20872929 (see for this abstract only)

Tue Sep 28, 2010 12:34 pm
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