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 RBD might be presymptomatic PD, DLB, or MSA 
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Post RBD might be presymptomatic PD, DLB, or MSA
The conclusion is not new -- RBD (REM sleep behavior disorder) can be a presymptomatic stage of PD, DLB, or MSA.

I believe the technique used to reach the conclusion may be new. Researchers studied cerebral blood flow in particular areas using SPECT. In those with RBD who did NOT have PD, DLB, or MSA, they found reduced blood flow in the brain.


European Journal of Neurology. 2010 Dec 12. [Epub ahead of print]

Regional cerebral blood flow changes in patients with idiopathic REM sleep behavior disorder.
Hanyu H, Inoue Y, Sakurai H, Kanetaka H, Nakamura M, Miyamoto T, Sasai T, Iwamoto T.

Department of Geriatric Medicine, Tokyo Medical University, Tokyo Japan Somnology Center, Neuropsychiatric Research Institute, Tokyo Department of Somnology, Tokyo Medical University, Tokyo Department of Neurology, Center of Sleep Medicine, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.

Background: Recent studies have shown an association between rapid eye movement sleep behavior disorder (RBD) and neurodegenerative disorders, especially alpha-synucleinopathies.

Objective: We investigated regional cerebral blood flow (rCBF) changes using single photon emission computed tomography (SPECT) in patients with idiopathic RBD (iRBD), to determine functional brain alterations associated with the disorder.

Methods: The SPECT data of 24 patients with iRBD were compared with those of 18 age-matched normal controls using statistical parametric mapping 2.

Results: We found decreased rCBF in the parietooccipital lobe (precuneus), limbic lobe, and cerebellar hemispheres in patients with iRBD, which is commonly seen in patients with Lewy body disease (Parkinson's disease and dementia with Lewy bodies) or multiple system atrophy.

Conclusion: Our SPECT study suggests that iRBD can be a presymptomatic stage of alpha-synucleinopathies.

© 2010 The Author(s). European Journal of Neurology © 2010 EFNS.

PubMed ID#: 21143707 (see for this abstract only)

Sun Dec 19, 2010 9:16 pm
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