Apathy and Depression predict MCI Progression

July 13, 2010 - Research by Mayo Clinic shows apathy and depression significantly predict if a person with mild cognitive impairment (MCI) may progress to dementia, including Lewy body dementia and Alzheimer’s disease. Researchers identified 358 individuals with MCI and used a questionnaire to collect data on depression and apathy. After a median of 2.8 years, out of 87 individuals with MCI who were depressed, 34.5 percent developed dementia, while those without depression developed dementia in only 21.8 percent of cases. Among the 60 people with MCI and apathy, 36.7 percent later developed dementia, compared to only 22.5 percent of those who did not have apathy.

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