What is this study about?
This study is investigating structural changes in the brain and how these changes relate to clinical symptoms in individuals with cognitive impairment due to Lewy body disease compared to individuals with cognitive impairment due to Alzheimer disease and to healthy adults. This study will also involve sharing of de-identified clinical, neurophysiological and imaging data with the University of Florida for collaborative study and analyses. De-identified means that your study data will be shared, but without personal identifiers, such as name or address, that would allow it to be connected to you. This ensures that participants’ privacy and confidentiality are maintained while allowing researchers to fully utilize the data.
What’s involved?
Participants will undergo structural magnetic resonance imaging (MRI), electroencephalography (EEG), electromyography (EMG), behavioral motor and cognitive assessments. Individuals will also complete questionnaires on your quality of life, health status, emotional state, mood, sleep, fluctuations in alertness and attention.
Who can participate?
An individual may be able to take part in the study if they:
- Are between the ages of 50-95 years old
- Have a primary language of English
- Are able and willing to undergo health and cognitive assessment, in addition to brain MRI and EEG study
- Have an available study partner who is familiar with participants daily functioning
- Have no significant sensory (visual and hearing) deficits
- Have no major psychiatric illness that would limit participation
- Have no major medical conditions that would limit participation
- Have no history of major neurological disorders including stroke, epilepsy, meningitis/encephalitis, metabolic or toxic encephalopathy, penetrating or severe head injury, brain tumor/other structural lesions
- Have no other primary movement disorders (such as essential tremors, dystonia, chorea, multiple system atrophy, progressive supranuclear palsy or corticobasal syndrome)
- Have no history of metalworking, involving cutting process such as grinding, filing, shaving and deep threading
- Have no history of claustrophobic anxiety
- Are not currently or planning to be pregnant
Study Site
Mayo Clinic Arizona in Scottsdale, Arizona
Study Sponsor
Mayo Clinic with collaboration from the National Institute on Aging
For more information
Please contact Emily Polgar via phone or email at 480-301-9789 and polgar.emily@mayo.edu.