Selectively Target Technology Development to Understand How Changes or Dysfunction at the Capillary, Arterioles, and Small Lymphatic Vessels Level Can Have Long-term Impact on AD/ADRD (R01 Clinical Trial Not Allowed)

The purpose of this Funding Opportunity Announcement (FOA) is to solicit studies that will advance the mechanistic understanding of small vessel vascular contributions to cognitive impairment and dementia (VCID) through the development of new technologies and innovative methods that enable the imaging and/or functional assessment of the small blood and lymphatic vessels and perivascular spaces of the brain.

This program aims to facilitate the development of tools and technology to image, profile and/or mechanistically characterize CNS small blood and lymphatic vessels in Alzheimer’s Disease and Alzheimer’s Disease-Related Dementia (AD/ADRD) animal models or patient populations. The overall goal is to use such technologies or methods to elucidate the mechanisms that link CNS small blood and lymphatic vessel dysfunction to dementia outcomes in the AD/ADRDs, their potential role in repair processes, and their response to therapies. Preclinical studies of small vessel VCID in vitro and/or animal models and pilot human subject studies (that do not meet the NIH definition of clinical trial) are appropriate for this FOA.