Continuum - Dementia with Lewy Bodies - 2007

Dementia with Lewy bodies (DLB) took many years to crystallize into a recognizable clinico-pathologic entity. Neuropathologic findings of a-synuclein
lesions in Lewy bodies and neurites correspond to dysfunction of the substantia nigra, and lesions in subcortical, limbic, and cortical regions are associated with  cognitive, neuropsychiatric, and motor manifestations, which may be modified by coexisting Alzheimer tangle pathology. Clinical diagnostic criteria combining cognitive  decline with features of parkinsonism, fluctuation of cognition, and visual hallucinations have been revised several times. The latest revision recognizes  the importance of REM sleep behavior disorder as a clinical feature and bridges DLB and Parkinson’s disease with dementia by removing an arbitrary 1-year  separation between onset of motor and cognitive symptoms. Neuropathologic diagnosis now assigns a weight to both a-synuclein and Alzheimer’s disease  lesions. Treatment remains symptomatic and usually requires sensitive manipulation of a combination of medications to try to stabilize or improve cognitive,  behavioral, and motor symptoms while minimizing side effects.

The American Academy of Neurology has granted permission to use this article. Reprinted with permission from Galasko DR. Dementia with Lewy bodies.  Continuum Lifelong Learning Neurol 2007;13(2):69-86. Copyright © 2007, American Academy of Neurology. All rights reserved.

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NOTE:  This review preceded the Black Box warnings on atypical antipsychotic drugs. These drugs do have a potential place in the management of behavioral symptoms in Lewy Body disorders. For further information on this topic, please refer to two recent publications by LBDA:  

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