What is this study about?
This study is examining if measurements of the eye can be used with other tests to detect dementia earlier. By comparing the results of non-invasive tests similar to those done in an eye doctor’s office with established tests of cognition, magnetic resonance imaging (MRI) and a positron emission tomography (PET) scan, researchers can look for links between changes in parts of the eye and dementia.
What’s involved?
Participants will attend 4-5 visits over 4 months. The visits will include undergoing brain imaging (MRI, PET), cognitive testing, gait and balance assessments, eye-imaging, cognitive and functional questionnaires, and giving blood samples.
Who can participate?
An individual may be able to take part in the study if they are:
- 50 years or older
- Fit one of the following categories:
- Diagnosed with Lewy body spectrum disorders (including PDD or DLB), Alzheimer’s disease, or vascular cognitive impairment (VCI)
- No history of Lewy body dementia, mild cognitive impairment, Alzheimer’s disease, or VCI to participate as a control
Study Sites
Interested individuals should contact Aparna Bhan (aparna.bhan@sunnybrook.ca) and Zhala Taghi-Zada (zhala.taghi-zada@sri.utoronto.ca) for prescreening at Sunnybrook Health Sciences Centre in Ontario, Toronto, Canada. Participants may be referred to other sites within Toronto, Canada as applicable.
Study Sponsor
Sunnybrook Health Sciences Centre
For more information
For more information, please contact Aparna Bhan at Aparna.bhan@sunnybrook.ca.