LBDA

Researchers Seek Volunteers for Dementia Clinical Trials

Have you ever considered participating in a clinical trial as a healthy adult, or as a person with cognitive impairment? Today, at least 50,000 people (both healthy adults and those with mild cognitive impairment, dementia or Alzheimer’s disease) are needed for more than 175 clinical trials across the country. Gains made in these conditions often shed light into related disorders like Lewy body dementias, so this is an excellent opportunity to play an important role in dementia research.

Some of these studies are drug trials and others evaluate interventions like exercise or managing other health conditions like blood pressure. Each study has very specific criteria for the types of individuals it needs as participants. To succeed in finding the 50,000 people needed, researchers will screen at least a half a million potential volunteers.

Here are examples of a few studies that may provide insights relevant to LBD. A study in Durham, NC will examine the impact certain types of anesthesia have on cognition and Alzheimer’s disease biomarkers. This study is seeking healthy older adults who need surgery, and may help shed light on whether these drugs play a role in cognitive impairment. LBD families sometimes report that LBD symptoms initially appeared or worsened after surgery, so measuring changes in biomarkers for Alzheimer’s disease may provide critical insights for further study in related disorders.

Another study in Baltimore, MD is seeking individuals with dementia in order to study ways to reduce agitation in dementia. Agitation is common in LBD and difficult for caregivers to manage. In Los Angeles, CA, researchers are seeking individuals with mild cognitive impairment to examine the relationship between physical activity levels, brain structure, and memory function. This may provide insights into how to reduce the risk of developing disorders like LBD.

Interested individuals can search for clinical trials by location, key search terms, age of the participant, or browse by trial category. For more information about these and other clinical trials on mild cognitive impairment and dementia, visit www.nia.nih.gov/alzheimers/clinical-trials. Or, contact the ADEAR Center at 1-800-438-4380 (toll-free) or adear@nia.nih.gov. The ADEAR Center is a service of the National Institute on Aging, part of the National Institutes of Health.