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 Decreased alpha-synuclein serum levels in DLB 
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Joined: Fri Aug 11, 2006 1:46 pm
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Location: SF Bay Area (Northern CA)
Post Decreased alpha-synuclein serum levels in DLB
As the only way to diagnose DLB is upon brain autopsy, a worldwide effort is underway to find a biomarker that can be used to diagnose DLB during life. A biomarker test that has different results for DLB and Alzheimer's Disease patients is key.

This German research is part of the DLB biomarker search effort. The authors state: "Previous studies focusing on the measurement of alpha-synuclein in the cerebrospinal fluid (CSF) of DLB and AD patients have reported conflicting results. A simple blood test could facilitate diagnostics as it would be widely available, noninvasive, easy, economic and rapid to perform."

The research term compared (blood) serum alpha-synuclein levels in 40 DLB patients and controls, and 80 AD patients. They found "significantly reduced alpha-synuclein serum levels in DLB compared to both AD and control subjects." But there was insufficient "sensitivity and specificity to be of clinical use."

Their conclusion is: "Although these results do not justify a definition of serum alpha-synuclein as a potential single biomarker, results may contribute to a multimarker strategy in DLB diagnosis." And: "this finding supports the hypothesis that low alpha-synuclein serum levels in DLB patients may reflect accumulation of alpha-synuclein in the brain, which has to be proven in future studies."

Robin



Dementia and Geriatric Cognitive Disorders. 2011 Jul 13;31(6):413-416. [Epub ahead of print]

Decreased alpha-Synuclein Serum Levels in Patients with Lewy Body Dementia Compared to Alzheimer's Disease Patients and Control Subjects.

Laske C, Fallgatter AJ, Stransky E, Hagen K, Berg D, Maetzler W.
Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.

Abstract
Background/Aims: Detection and differentiation of neurodegenerative dementias, such as dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), with blood-based biomarkers would facilitate diagnosis and treatment.

Methods: By use of a commercially available ELISA kit, we measured alpha-synuclein levels in the serum of 40 DLB patients and controls, and of 80 AD patients.

Results: We found significantly reduced alpha-synuclein serum levels in DLB compared to both AD (p = 0.006) and control subjects (p = 0.001), reaching an area under the curve of >0.70.

Conclusion: Although these results do not justify a definition of serum alpha-synuclein as a potential single biomarker, results may contribute to a multimarker strategy in DLB diagnosis.

Copyright © 2011 S. Karger AG, Basel.

PubMed ID#: 21757905 (see pubmed.gov for this abstract only)


Mon Jul 18, 2011 1:20 am
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Joined: Wed Dec 30, 2009 1:46 pm
Posts: 3213
Location: WA
Post Re: Decreased alpha-synuclein serum levels in DLB
Certainly sounds like they're on the right track.

_________________
Pat [68] married to Derek [84] for 38 years; husband dx PDD/LBD 2005, probably began 2002 or earlier; late stage and in a SNF as of January 2011. Hospitalized 11/2/2013 and discharged to home Hospice. Passed away at home on 11/9/2013.


Mon Jul 18, 2011 9:50 am
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Joined: Fri Aug 11, 2006 1:46 pm
Posts: 4811
Location: SF Bay Area (Northern CA)
Post Re: Decreased alpha-synuclein serum levels in DLB
Yes, it's just taking a long time.


Mon Jul 18, 2011 11:59 pm
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