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 cholinesterase inhibitor (ChEI) 
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Joined: Sun May 01, 2011 3:34 pm
Posts: 2
Location: San Francisco Bay Area
Post cholinesterase inhibitor (ChEI)
In the latest e-newsletter, this association mentioned the cholinesterase inhibitor (ChEI). Has anyone had any experience using this drug?
Thanks.


Sun Aug 19, 2012 8:27 pm
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Joined: Wed Dec 30, 2009 1:46 pm
Posts: 3176
Location: WA
Post Re: cholinesterase inhibitor (ChEI)
My husband has been on the Exelon patch for over five years. It is one type of cholinesterase inhibitor. Aricept is one, as well. The Exelon patch helped dramatically at first. There is simply no way to know whether or not it is still effective but we are choosing to keep him on it.

_________________
Pat [68] married to Derek [84] for 38 years; husband dx PDD/LBD 2005, probably began 2002 or earlier; late stage and in a SNF as of January 2011. Hospitalized 11/2/2013 and discharged to home Hospice. Passed away at home on 11/9/2013.


Tue Aug 21, 2012 3:09 pm
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Joined: Sun May 01, 2011 3:34 pm
Posts: 2
Location: San Francisco Bay Area
Post Re: cholinesterase inhibitor (ChEI)
Thanks for your input. How did it help? What dramatic change(s) did you see? Our doctor thinks it is good for agitation and hallucinations, neither of which my husband (age 81) has experienced as yet.


Tue Aug 21, 2012 6:27 pm
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Joined: Wed Dec 30, 2009 1:46 pm
Posts: 3176
Location: WA
Post Re: cholinesterase inhibitor (ChEI)
There was improved cognition with the low dose [4.6mg] Exelon patch and he became less agitated. There was no discernible improvement with the higher [9.5mg] dose patch but the doctors have kept him on the 9.5mg and say that they don't prescribe the 4.6 as a maintenance dose.

_________________
Pat [68] married to Derek [84] for 38 years; husband dx PDD/LBD 2005, probably began 2002 or earlier; late stage and in a SNF as of January 2011. Hospitalized 11/2/2013 and discharged to home Hospice. Passed away at home on 11/9/2013.


Tue Aug 21, 2012 7:21 pm
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Joined: Fri Jan 15, 2010 9:33 pm
Posts: 3118
Location: Vermont
Post Re: cholinesterase inhibitor (ChEI)
My dad was on Aricept and Namenda, which increased his cognition for a while, but also made him painfully aware of how incapacitated he was. Overall, it got to be a very negative thing and I tried to have him taken off those drugs. If I could change anything, I'd have had his atty. file a suit to get him off the drugs, or I would have moved him out of state to where I live. In the longrun, his last months were MUCH more miserable because of the Namenda and Aricept. He'd finally gotten to the lalaland state of not knowing just how bad off he was a few months prior to his dr. giving him these 2 drugs without my POA consent. Many people find those drugs very helpful - it is all so individual and they are certainly worth a try, but getting someone off them is important if their overall health and happiness are worse. Good luck, Lynn

_________________
Lynn, daughter of 89 year old dad dx with possiblity of LBD, CBD, PSP, FTD, ALS, Vascular Dementia, AD, etc., died Nov. 30, 2010 after living in ALF for 18 months.


Tue Aug 21, 2012 8:01 pm
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