Joined: Fri Aug 11, 2006 1:46 pm
Location: SF Bay Area (Northern CA)
PD Research into Sleepwalking
A few of you have mentioned sleepwalking. After reading this abstract today, I wondered if sleepwalking in Parkinson's Disease (PD) is an indicator of Parkinson's Disease Dementia (also called Lewy Body Dementia).
Based upon questionnaires given to PD patients in Switzerland, researchers found that patients who sleepwalked:
* had significantly longer disease duration
* reported more often hallucinations and nightmares
* had scores that suggested they may have RBD
* were sleepier
Here's the abstract.
Journal of Neurology. 2011 Feb 4. [Epub ahead of print]
Sleepwalking in Parkinson's disease: a questionnaire-based survey.
Oberholzer M, Poryazova R, Bassetti CL.
Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland.
Sleepwalking (SW) corresponds to a complex sleep-associated behavior that includes locomotion, mental confusion, and amnesia. SW is present in about 10% of children and 2-3% of adults. In a retrospective series of 165 patients with Parkinson's disease (PD), we found adult-onset ("de novo") SW "de novo" in six (4%) of them.
The aim of this study was to assess prospectively and systematically the frequency and characteristics of SW in PD patients. A questionnaire including items on sleep quality, sleep disorders, and specifically also SW and REM sleep behavior disorder (RBD), PD characteristics and severity, was sent to the members of the national PD patients organization in Switzerland.
In the study, 36/417 patients (9%) reported SW, of which 22 (5%) had adult-onset SW. Patients with SW had significantly longer disease duration (p = 0.035), they reported more often hallucinations (p = 0.004) and nightmares (p = 0.003), and they had higher scores, suggestive for RBD in a validated questionnaire (p = 0.001). Patients with SW were also sleepier (trend to a higher Epworth Sleepiness Scale score, p = 0.055).
Our data suggest that SW in PD patients is (1) more common than in the general population, and (2) is associated with RBD, nightmares, and hallucinations.
Further studies including polysomnographic recordings are needed to confirm the results of this questionnaire-based analysis, to understand the relationship between SW and other nighttime wandering behaviors in PD, and to clarify the underlying mechanisms.
PMID: 21293874 (see pubmed.gov for abstract only)
Joined: Wed Oct 28, 2009 11:53 am
Location: Ocala, FL
Re: PD Research into Sleepwalking
Thank you, Robin.
Dale often fell to sleep during ordinary conversations - even when he had plenty of sleep. He regularly fell to sleep during sermons... which used to annoy me. I have no doubt that there is a connection with what he has now.
He did not have the typical symptoms of Parkinson's ... no tremor. However, he had significant dizziness for several years prior to the diagnosis in 09.
Leone Carroll (75); wife of Dale (75) who passed away March 23, 2011