Hypermetabolism in DLB may be related to VH
The researchers gave FDG-PETs to 22 people within two months of a clinical diagnosis of probable DLB. The authors concluded that "Hypermetabolism is common in patients with DLB and may be related to visual hallucinations."
The abstract is copied below.
Clinical Nuclear Medicine. 2010 Jul;35(7):490-3.
Hypermetabolism in patients with dementia with Lewy bodies.
Miyazawa N, Shinohara T, Nagasaka T, Hayashi M.
Department of PET Center of Kofu Neurosurgical Hospital, Kofu, Yamanashi, Japan. email@example.com
PURPOSE: Detection of hyperperfusion by I-123 N-isopropyl-p-iodoamphetamine single photon emission computed tomography can be helpful to diagnose dementia with Lewy bodies (DLB). This study characterized hypermetabolism in DLB.
MATERIALS AND METHODS: A total of 22 probable cases of DLB were examined by F-18 2-fluoro-2-deoxy-D-glucose positron emission tomography.
RESULTS: Hypermetabolism was found in the peri-motor area, basal ganglia, and cerebellum. Eleven patients had hypermetabolism in all 3 areas, 6 in 2 areas, 4 in 1 area, and 1 in no area. Hypermetabolism was most frequent in the cerebellum. Comparison of the 11 patients with hypermetabolism in all 3 areas to the other 11 cases found no significant differences in age (P = 0.2555), sex (P = 0.1889), Mini-Mental State Examination score (P = 0.0897), and Parkinsonism. However, visual hallucinations were significantly more frequent in the patients with hypermetabolism in all 3 areas (P = 0.0018).
CONCLUSIONS: Hypermetabolism is common in patients with DLB and may be related to visual hallucinations.
PubMed ID#: 20548139 (see pubmed.gov for this abstract only)