Re: Up to 50% of AD cases exhibit Lewy bodies
This commentary from two leading Seattle-based dementia researchers is about the mouse model described back in June (see earlier post). These mice had both DLB and AD pathologies in their brains. This commentary is an explanation of the importance of this particular mouse model. Further, it's an explanation of the links between AD, PD, PDD, and DLB. I found the first few paragraphs understandable along with the last paragraph.
The commentary is currently available for free online at:http://alzres.com/content/2/5/26
(Save this article now to your hard drive if you want it. I've found that just because things are available for free now doesn't mean they'll be available for free in the future.)
The commentary's citation (PubMed ID#: 20854651) and abstract follow.
Alzheimer's Research & Therapy 2010 Sep 17;2(5):26.
From model system to clinical medicine: pathophysiologic links of common proteinopathies.
McMillan PJ, Leverenz JB.
Mental Illness Research Education and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, WA.
Recent clinical evidence suggests that Alzheimer disease (AD), Parkinson disease (PD), and dementia with Lewy bodies (DLB), though distinct neurological disorders, have some common pathological features that may have an impact on the clinical characteristics of these diseases. However, the question of whether these disorders have a common pathophysiology remains. Clinton and colleagues recently reported a mouse model that exhibits the combined pathologies of AD, PD, and DLB, a finding that may shed some light on this issue. Using this mouse model, the authors demonstrate that the pathogenic proteins amyloid beta, tau, and alpha-synuclein interact synergistically to enhance the accumulation of one another and accelerate cognitive decline. These data indicate shared pathogenic mechanisms and suggest the possibility that therapeutic interventions successfully targeting one of these pathogenic proteins have implications for a number of related neurodegenerative disorders.