Biomarkers summary article
An article summarizing the "investigations addressing the field of the early neurochemical differential diagnosis of Parkinson syndromes and the early diagnosis of Parkinson dementia" and providing an overview of the tested biomarkers was published over the summer 2090 by German researchers.
The authors conclude that "the specific biomarker for a certain neurological disease is yet to be identifiedâor better, several biomarkers. We think that a combination of multiple or at least two proteins will be necessary to differentiate [parkinsonian syndromes] as well as dementing syndromes from each other, as demonstrated for AD (tau/AÃ) and CJD (tau, protein S-100B, and protein 14â3-3). Furthermore, we assume that the diagnostic question has to be very precise (e.g., PD or PDD, MSA versus PD)."
This full article is available online for free. See:
http://www.ncbi.nlm.nih.gov/pmc/article ... ool=pubmed
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http://www.ncbi.nlm.nih.gov/pmc/article ... 5-0157.pdf
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This table, in particular, lists all of the possible biomarkers for PD, PDD, DLB, PSP, and MSA:
http://www.ncbi.nlm.nih.gov/pmc/article ... ble/tbl17/
For me, the most interesting section of the article was about metals and whether they increase the risk for these diseases. (See "Metals: Believed to Be (Co)Factors of Aggregation") I understood very little of that section of the article but others of you will have a better chance.
Another interesting section was about the use of heart fatty acid-binding protein to differentiate PD from DLB and PD from PDD.