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 With RBD, high risk of developing neurodegenerative disease 
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Post With RBD, high risk of developing neurodegenerative disease
This Canadian research looks at 93 people with a diagnosis of idiopathic RBD (REM sleep behavior disorder). So when these people were first diagnosed with RBD, they had no signs of a neurodegenerative disorder. Within this group, the "estimated 5-year risk of neurodegenerative disease was 17.7%, the 10-year risk was 40.6%, and the 12-year risk was 52.4%. ... Although we have found a slightly lower risk than other reports, the risk of developing neurodegenerative disease in idiopathic REM sleep behavior disorder is substantial, with the majority of patients developing Parkinson disease and Lewy body dementia." In the study group, 14 developed PD, 7 developed LBD, 4 developed AD, and one developed MSA.
Robin


Neurology. 2009 Apr 14;72(15):1296-300. Epub 2008 Dec 24.

Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder.

Postuma RB, Gagnon JF, Vendette M, Fantini ML, Massicotte-Marquez J, Montplaisir J.
Department of Neurology, Montreal General Hospital, Montreal, Quebec, Canada.

OBJECTIVE: Idiopathic REM sleep behavior disorder (RBD) is a potential preclinical marker for the development of neurodegenerative diseases, particularly Parkinson disease (PD) and Lewy body dementia. However, the long-term risk of developing neurodegeneration in patients with idiopathic RBD has not been established. Obtaining an accurate picture of this risk is essential for counseling patients and for development of potential neuroprotective therapies.

METHODS: We conducted a follow-up study of all patients seen at the sleep disorders laboratory at the Hôpital du Sacré Coeur with a diagnosis of idiopathic RBD. Diagnoses of parkinsonism and dementia were defined according to standard criteria. Survival curves were constructed to estimate the 5-, 10-, and 12-year risk of developing neurodegenerative disease.

RESULTS: Of 113 patients, 93 (82%) met inclusion criteria. The mean age of participants was 65.4 years and 75 patients (80.4%) were men.

Over the follow-up period, 26/93 patients developed a neurodegenerative disorder. A total of 14 patients developed PD, 7 developed Lewy body dementia, 4 developed dementia that met clinical criteria for AD, and 1 developed multiple system atrophy.

The estimated 5-year risk of neurodegenerative disease was 17.7%, the 10-year risk was 40.6%, and the 12-year risk was 52.4%.

CONCLUSIONS: Although we have found a slightly lower risk than other reports, the risk of developing neurodegenerative disease in idiopathic REM sleep behavior disorder is substantial, with the majority of patients developing Parkinson disease and Lewy body dementia.

PubMed ID#: 19109537 (see pubmed.gov for abstract only)


Sun May 03, 2009 6:50 pm
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