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 Molecular pathology of Lewy body diseases (Spanish paper) 
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Post Molecular pathology of Lewy body diseases (Spanish paper)
Probably few of you are interested in this abstract of a medical journal article. This confirms that researchers believe the "key pathogenic event" in Dementia with Lewy Bodies is the aggregation of the protein alpha-synuclein in the brain. And widespread "mitochondrial dysfunction is very closely related to disease development." The Spanish authors discuss "genes primarily involved in Lewy body formation." I assume these are the genes we know about, including LRRK2. Few people with Lewy body disorders (such as PD and DLB) have these genetic mutations.

International Journal of Molecular Sciences. 2009 Mar;10(3):724-45. Epub 2009 Feb 26.

Molecular pathology of lewy body diseases.

Beyer K, Domingo-Sàbat M, Ariza A.
Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Barcelona, Spain.

Lewy body diseases are characterized by the presence of Lewy bodies, alpha-synuclein(AS)-positive inclusions in the brain. Since their main component is conformationally modified AS, aggregation of the latter is thought to be a key pathogenic event in these diseases. The analysis of inclusion body constituents gives additional information about pathways also involved in the pathology of synucleinopathies. Widespread mitochondrial dysfunction is very closely related to disease development. The impairment of protein degradation pathways, including both the ubiquitin-proteasome system and the autophagy-lysosome pathway also play an important role during the development of Lewy body diseases. Finally, differential expression changes of isoforms corresponding to genes primarily involved in Lewy body formation point to alternative splicing as another important mechanism in the development of Parkinson's disease, as well as dementia with Lewy bodies. The present paper attempts to give an overview of recent molecular findings related to the pathogenesis of Lewy body diseases.

PubMed ID#: 19399218 (see for abstract only)

Wed Apr 29, 2009 10:54 pm
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