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 Biobanks for biomarkers in LBD, etc. 
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Joined: Fri Aug 11, 2006 1:46 pm
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Location: SF Bay Area (Northern CA)
Post Biobanks for biomarkers in LBD, etc.
Based on the abstract, this looks like an interesting article from a few perspectives. First, it reviews what we already know about biomarker research. Second, it makes the point that "brain/tissue/biobanks (BTB-banks) will have a major role in identifying the relevant biomarkers and will collect, preserve and type RNA and DNA extracted from brain/tissue/body fluids in order to update the pathological hallmarks of dementing disorders."

One thing I'd like to investigate is donating CSF (cerebrospinal fluid) upon death. I helped someone in another state make arrangements for brain donation; the family topped that by donating CSF as well.


Journal of Neurological Sciences. 2009 Mar 24. [Epub ahead of print]

Biobanks for biomarkers in neurological disorders The Da Vinci bridge for optimal clinico-pathological connection.

Ravid R.
Netherlands Institute for Neurosciences, Amsterdam, The Netherlands.

The diagnosis of dementing disorders is severely hampered by the absence of reliable biomarkers that can be measured in body fluids such as blood, urine and cerebro-spinal fluid (CSF). Searching for biomarkers is hampered by the huge variability between individuals; the use of autopsy specimens induces significant data fluctuation due to rapid post-mortem changes in the specimens. The search for biomarkers obtained from living donors has contributed already a vast amount of data. The role of amyloid and tau as early diagnostic markers in the pathology of dementia has been reported in differential involvement in Alzheimer's disease (AD), late onset Alzheimer disease (LOAD), Lewy Body dementia (DLBD), Vascular dementia, fronto-temporal lobar degeneration (FTLD), Mild cognitive impairment (MCI) and non neurological controls. In the coming decennia, brain/tissue/biobanks (BTB-banks) will have a major role in identifying the relevant biomarkers and will collect, preserve and type RNA and DNA extracted from brain/tissue/body fluids in order to update the pathological hallmarks of dementing disorders. The present paper reviews and compares the currently known/clinically applied biomarkers in dementia which can be identified and incorporated into clinical drug trials and elucidate proposed mechanisms of disease and drug action. Furthermore, the review screens a panel of biomarkers used for early and differential diagnosis and comments on the validity of these biomarkers in reflecting the typical hallmarks of neurological disorders.

PMID: 19324376


Sat Mar 28, 2009 11:39 pm
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