This November '08 article may be of interest because over one-third of the patients diagnosed in this study had their diagnoses changed from PD to DLB later on. When the change was from PD to DLB or essential tremor, diagnostic "changes were most commonly a result of development of additional features, particularly early cognitive impairment and neuropsychiatric features, the results of radiological imaging, poor response to levodopa and lack of disease progression."
My November post below provided the text of a Reuters Health article written about this UK research. The research paper itself is available online at: (currently, it's free)
http://jnnp.bmj.com/cgi/reprint/79/11/1202
The tables, in particular, are worthwhile. I'd suggest scanning the tables for the disorders that interest you.
This paragraph from the Discussion section is worth noting: "Changing [diagnoses] between different parkinsonian syndromes may not alter management so dramatically as a trial of dopamine replacement therapy is often warranted but it will alter what information is given to the patient about prognosis. In addition, some clinicians may wish to avoid early levodopa in those with PD because of the risk of motor complications, while treatment withdrawal should always be considered where the syndrome is thought to be unresponsive. Similarly, while many experts would regard PD and DLB as being part of the same disease spectrum, we regarded them separately because their prognosis differs and dopamine agonists may be less suitable in DLB because of their greater neuropsychiatric toxicity."
I learned a few things from reading the full article. First, there is a Mini-Mental Parkinson (MMP) test available; it's a PD specific cognitive screening tool. "The MMSE and MMP may...be of some use in identifying parkinsonian patients who will go on to develop early dementia, although a larger study is needed to test this hypothesis." Second, PD is over-diagnosed. Third, "there have been reports of pathologically established cases of PD without an appreciable response to levodopa, making clinical diagnosis in life extremely difficult."
Here are extensive excerpts:
"Accurate diagnosis of PD is important both in clinical practice, where it will influence management, and in research, where the validity of findings may be compromised if studies include heterogenous conditions. This importance is likely to grow as neuroprotective strategies are developed that target specific pathological processes."
"Antemortem diagnosis currently relies on clinical assessment but, in most post-mortem series, the positive predictive value (PPV) of the final clinical diagnosis of PD has only been found to be between 76% and 90%. This can be improved with application of strict diagnostic criteria. For example, retrospective application of the UK Brain Bank diagnostic criteria improved the PPV in one study from 76% to 93%. However, application of these criteria meant that 32% of those with pathologically proven PD were not diagnosed clinically. Thus strict research based criteria increase specificity at the cost of reducing sensitivity."
"Much of the difficulty in the diagnosis of PD is in differentiating it from other disorders that cause parkinsonism. These include other neurodegenerative disorders such as dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP), multiple system atrophy and corticobasal degeneration, and non-degenerative causes such as vascular parkinsonism or drug induced parkinsonism (eg, as a result of antidopaminergic drugs). Difficulty in initial diagnosis is further compounded by the existence of non-parkinsonian disorders that can mimic parkinsonism. Particular problems are presented by tremor disorders, most notably essential tremor, and primary gait disorders, especially higher level disorders such as those associated with cerebrovascular disease. The increasing prevalence of multiple comorbidities with age can further complicate matters. Indeed, general slowing in the elderly can be confused with bradykinesia, with subtle extrapyramidal signs being reported in up to 35% of subjects older than 65 years."
"Although diagnosing the cause of parkinsonism is problematic, few studies have systematically assessed changes in the clinical diagnosis over time. One study found that in a cohort of patients with early presumed PD, 8% had their diagnosis changed after a mean follow-up of 6 years because of either a poor levodopa response, the development of atypical clinical features, atypical imaging findings or post mortem."
"As part of the PINE pilot study, all patients from the lists of 18 general practices in Aberdeen (a population of approximately 148,000) presenting with a newly diagnosed possible or definite parkinsonian syndrome (excluding definite drug induced parkinsonism) were recruited by multiple overlapping strategies over an 18 month period. All were seen by a consultant neurologist with a special interest in PD or a supervised trainee, and underwent a standardised baseline assessment, including the Unified Parkinsonâs Disease Rating Scale (UPDRS) with video recording of the motor section, and assessment of atypical features, such as dysautonomia, gaze palsy and cognitive or psychiatric symptoms. In those who consented to detailed follow-up, cognitive testing was carried out using the Mini-Mental State Examination (MMSE) and the Mini-Mental Parkinson (MMP), a PD specific cognitive screening tool. Consenting patients had repeat yearly assessments with planned lifelong follow-up..."
"Patients were asked to consent to undergo structural neuroimaging with either CT or MRI and functional imaging of dopamine transporter uptake with N-v-fluoropropyl-2bcarbomethoxy-3b-(4-iodophenyl)-tropane (FP-CIT) single photon emission computed tomography (SPECT). FP-CIT SPECT scans were visually graded by a blinded consultant neuroradiologist as normal, abnormal or atypical (ie, abnormal but not in keeping with the pattern usually seen in neurodegenerative disease). CT and MRI images were assessed visually for burden of cerebrovascular disease and, in the case of MRI, midbrain atrophy and basal ganglia signal change but no formal criteria were applied."
"At baseline and at each yearly follow-up, the assessing (unblinded) clinician recorded up to three most likely clinical diagnoses without applying research criteria and gave a percentage certainty for each (eg, 90% certain PD). ... All available information was used to inform these diagnoses, including the results of any structural or functional imaging tests that were available at each assessment. Baseline diagnoses were reached after initial clinical assessment, before formal cognitive testing had been carried out."
"On each patientâs death, a final assessment was carried out, with review of general practitioner, hospital and research records, imaging tests and taking into account the results of post-mortem examinations where available. A final clinical or pathological diagnosis was then recorded."
"In this study, 4 years after the beginning of the incident period, the initial and latest clinical diagnoses (the one with the highest percentage certainty) were compared for all incident patients who had at least 1 year of follow-up data and the reason for any change identified from the notes. In those patients who died, the final clinical diagnosis was taken from the yearly assessment immediately prior to death. Formal research criteria were then applied retrospectively using patientsâ research records at baseline and latest yearly followup. For 37 of the patients, these criteria were applied independently by two assessors and the diagnoses reached were compared to assess inter-rater reliability. Differences in diagnosis were resolved by discussion. The criteria applied were as follows: the UK Brain Bank criteria for PD, the consensus criteria for DLB, the consensus criteria for multiple system atrophy, the Litvan criteria for progressive supranuclear palsy, Leesâ proposed criteria for vascular parkinsonism and the Lang criteria for corticobasal degeneration disregarding cognitive decline as a criterion for exclusion. Where patients met more than one set of criteria, a single best fit diagnosis was decided upon by consensus of two authors based on the information available."
"Of 82 incident patients identified, five were excluded from this study because they did not consent to follow-up and 11 were excluded because they died before their first yearly follow-up. The 66 remaining patients had a mean age of 75.0 years at diagnosis and were predominantly male (62%). At the initial assessment, symptoms had been present for a median of 12.5 months. Twenty-four patients died after at least 1 year of follow-up but no other patients were lost to follow-up. Only five patients had undergone examination of the brain at post mortem."
"Change in clinical diagnosis
Forty-six patients (70%) were initially diagnosed with idiopathic PD, with the most common alternate diagnoses being vascular parkinsonism, multiple system atrophy (all parkinsonian variant) and essential tremor (diagnosed in three patients; table 1). After a median follow-up of 29 months, the number diagnosed clinically with PD had fallen to 37 (56%), the most common alternative diagnoses being vascular parkinsonism and DLB."
"The clinical diagnosis changed between the baseline assessment and the latest follow-up in 22 patients (33%) and remained unchanged in 44 (table 2). There was no significant difference between these two groups in presenting symptoms, severity of their parkinsonian impairment (UPDRS) or duration of their symptoms at baseline (table 3). There was a nonsignificant trend towards greater cognitive impairment (MMSE and MMP) and older age in the group whose diagnoses changed. Most (18, 82%) changes occurred in the first year, three (6% of those with at least 2 years of follow-up) occurred within the second and one (3% of those with at least 3 years of follow-up) within the third."
"In those initially diagnosed with PD, the diagnosis was most likely to change to DLB (5/13, 38%) or essential tremor (3/13, 23%) (table 4). Changes were most commonly a result of development of additional features (n=7), particularly early cognitive impairment and neuropsychiatric features (n=5), the results of radiological imaging (n=6), poor response to levodopa (n=4) and lack of disease progression (n=6)."
"Changes in diagnosis in those initially diagnosed with conditions other than PD are shown in table 4. Changes were to PD (4/9, 44%), vascular parkinsonism (3/9, 33%) or DLB (2/9, 22%). The predominant reason for change to a diagnosis of PD was response to levodopa."
"Differences between latest clinical diagnosis and research diagnosis
Agreement between the two observers on the research criteria diagnosis was good (k=0.73), and agreement between research diagnosis and clinical diagnosis was very good (k=0.82). Details of the eight participants whose clinical and research diagnoses differed are shown in table 5."
"In the five patients who underwent post-mortem examination, the final clinical, research and pathological diagnoses agreed in two (one PD and one vascular) and in one the clinical diagnosis and pathological diagnosis agreed (PD with coexistent Alzheimerâs disease) while research criteria suggested possible DLB. The two participants whose clinical and antemortem research diagnoses were PD but whose post-mortem examinations showed PSP are described in table 5."
"DISCUSSION
In this study, one-third of the initial diagnoses of the cause of parkinsonism changed over a median of 29 months of followup. The majority of this change was a result of initial overdiagnosis of PD. The proportion of patients diagnosed with PD fell by 14% and most (59%) diagnostic changes were away from PD. These results are similar to previous studies, which showed that the clinical diagnosis of parkinsonism changed over time in 36% of patients attending a highly specialist clinic, and 16% of an incident cohort of patients with PD according to UK Brain Bank criteria had their initial diagnosis changed after about 3.5 years of follow-up."
"Over one-third (38%) of those misdiagnosed with PD had their diagnosis changed to DLB. This was usually because the symptomatic cognitive features of the disease were absent initially as, even using the strictest interpretation of the diagnostic criteria, parkinsonism can predate the onset of dementia by up to 1 year. However, the suggestion of a difference in cognitive scores between the change and no change groups would suggest that there may have been detectable deficits despite the lack of cognitive symptoms. The MMSE and MMP may, therefore, be of some use in identifying parkinsonian patients who will go on to develop early dementia, although a larger study is needed to test this hypothesis."
"Changes in diagnosis were usually as a result of level of response to treatment with levodopa or a dopamine agonist, lack of progression and development or resolution of atypical clinical features. This serves to highlight the need for regular follow-up and diagnostic revision in parkinsonian patients, and the diagnostic value of a trial of therapy. However, the results of therapeutic trials must be interpreted with caution, as PD may not show the classical excellent response to treatment, and there have been reports of pathologically established cases of PD without an appreciable response to levodopa, making clinical diagnosis in life extremely difficult. The role of functional imaging in the changes to diagnosis that took place is unclear. The results of FP-CIT SPECT scans supported change from initial clinical diagnoses in six patients, although in all but one of these cases (patient No 14, table 4), the clinical features were present that may have led to the change independently." [Robin's note: The diagnosis for patient #14 was changed from DLB to vascular parkinsonism.]
"The latest clinical diagnosis differed from the diagnosis on research criteria in eight patients (12%; table 5) usually because of exclusion criteria within the research criteria (patient Nos 23 and 24), or arbitrary time limits within the criteria (patient Nos 28 and 29)." [Robin's note: The diagnosis for patient #23 was changed from PD with concurrent AD to DLB, and for patient #24 from PD to MSA.]
"In two cases (patient Nos 25 and 30) there were features to support both diagnoses and it could be argued that either could be applied." [Robin's note: The diagnosis for patient #25 was changed from PD to MSA, and for patient #30 from DLB to vascular parkinsonism.]
"...there are also some limitations of this study that are worth noting. Firstly, our cohort was relatively small as it was drawn from a pilot study. A larger incidence study is currently underway and will allow analysis of similar data in a larger population. Secondly, while the revised diagnoses here are taken to be correct, it is likely that they will continue to change over time. Follow-up of this cohort will continue and so it will be possible to report the pattern of changes with longer followup in the future. Thirdly, the diagnoses were all supervised by a single consultant with an interest in PD and so our results may not be generalisable, particularly to more generalist clinics where the misdiagnosis rate may be higher. Finally and importantly, few diagnoses have been confirmed by post mortem and, therefore, it is not clear whether either the clinical or antemortem research diagnoses are correct. This is a problem with all clinical studies of parkinsonism but, because we have systematically tried to approach our participants for antemortem consent, we hope to obtain pathological confirmation in more of our participants over time. Studies of diagnostic accuracy that used brain bank material had the advantage of complete pathological confirmation but were disadvantaged by limited clinical information on which to base research diagnostic criteria and limited generalisability because post mortems are often performed on unusual or difficult cases."
"The clinical significance of misdiagnoses in parkinsonism varies. A change in diagnosis between a parkinsonian condition and a non-parkinsonian one (such as essential tremor) will have a significant impact on patient care as the treatments are quite different. Changing between different parkinsonian syndromes may not alter management so dramatically as a trial of dopamine replacement therapy is often warranted but it will alter what information is given to the patient about prognosis. In addition, some clinicians may wish to avoid early levodopa in those with PD because of the risk of motor complications, while treatment withdrawal should always be considered where the syndrome is thought to be unresponsive. Similarly, while many experts would regard PD and DLB as being part of the same disease spectrum, we regarded them separately because their prognosis differs and dopamine agonists may be less suitable in DLB because of their greater neuropsychiatric toxicity."
"In summary, we have demonstrated that even in those with a special interest, the accurate diagnosis of the cause of parkinsonism at presentation was difficult, that PD was overdiagnosed at first assessment and that research criteria were often unhelpful in clarifying the diagnosis, even after a median of 29 months of follow-up. Further research, in larger groups and over longer periods, is necessary to identify factors that may be used to improve the accuracy of diagnosis at the initial assessment. Our findings support the recent NICE guidelines that regular clinical review of those suffering from parkinsonism with careful attention to the diagnosis is essential in order that they receive appropriate care."
