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 Has anyone got similar serum amino acid results to me? 
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Joined: Mon Sep 30, 2013 11:16 pm
Posts: 25
Post Has anyone got similar serum amino acid results to me?
There is quite a bit of evidence to suggest that there may be metabolic disorders underpinning at least some cases of dementia and possibly many cases. If a metabolic disorder is causing the disease, understanding the metabolic disorder that is causing the disease could be crucial to getting treatment aimed at the individual.

I have the following abnormal serum amino acid results - low ornithine, low serine and borderline low/low taurine. There is some evidence that low taurine is a biomarker for risk of Parkinson's which my gran had and which I and my father have had early onset symptoms of.

Has anyone else had their serum amino acids tested and got similar results to me? I think these abnormal results in me are the biomarkers of a dominantly inherited metabolic disorder that inter-alia causes dementia. There is a good possibility I have found the reason for these abnormal results in me, which should help with getting me the right treatment. I am wating to hear from my metabolic specialist if I am right as to the likely/possible cause. So I would be interested to hear if any of you have the same results and have any information.

I add that patterns of amino acid biomarkers are used to help identify some known metabolic disorders. For example, known P5CS disorders present with low serum amino acids ornithine, citrulline and arginine as biomarkers. Inter-alia P5CS disorders cause neurodegeneration.

Finding out what exactly is causing serum amino acid abnormalities, if you have them, could be helpful in finding the right treamtent. Unfortunately, there are probably numerous metabolic disorders presenting with different patterns of serum amino acid abnormalities that cause many of those cases of dementia that result from metabolic disorders. In most cases these patterns of serum amino acid abnormalities are not yet understood. But at least if you know you have a pattern of serum amino acid abnormalities, you know what may be the biomarkers of your condition.

Wed Oct 02, 2013 5:52 am

Joined: Wed Dec 30, 2009 1:46 pm
Posts: 3213
Location: WA
Post Re: Has anyone got similar serum amino acid results to me?
Interesting. I don't think most people are even tested for amino acid abnormalities.

Pat [68] married to Derek [84] for 38 years; husband dx PDD/LBD 2005, probably began 2002 or earlier; late stage and in a SNF as of January 2011. Hospitalized 11/2/2013 and discharged to home Hospice. Passed away at home on 11/9/2013.

Wed Oct 02, 2013 10:28 am

Joined: Mon Sep 30, 2013 11:16 pm
Posts: 25
Post Re: Has anyone got similar serum amino acid results to me?
I think that it is highly probable amino acids are not tested in most people.

But type 'dementia amino pubmed' into google to see some of the research. Much of the research is oldish and when it was done inborn errors of metabolism were relatively new concepts. Like I said, these days abnormal patterns of amino acid abnormalities are a diagnostic tool utilised to help diagnose some inborn errors of metabolism.

My view is that once those disorders that present with abnormal amino acid profiles begin to be investigated as resulting from metabolic defects, inborn or acquired, progress will be made in finding the causes and in treatment.

Wed Oct 02, 2013 7:25 pm
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