Curiously there were two brain donation cases I was involved in this year where the clinical DX was Lewy Body Dementia but the pathological diagnosis was PSP (with nary a Lewy body to be found).

Actually, one case was PSP + AgD, and the other was AD + PSP.

Neither of these patients had hallucinations, which are not required for LBD but you have to have either hallucinations or fluctuating cognition.

In the PSP + AgD case, I know the diagnosing neurologist well and am very surprised. Her reply: "humbling."

Of course this made no difference for the treatment but always leaves people reeling in terms of expectations.

And another recent case was:
clinical DX = LBD
path DX = CBD and AgD

This gentleman had hallucinations but they've now been explained as being medication-related. He did NOT have fluctuating cognition.

And a fourth case (where the caregiver was a member here) was:
clinical DX = LBD
path DX = "atypical PSP"

I'm not sure if this gentleman had hallucinations or fluctuating cognition. I'd have to look back at the caregiver's posts.

What's AgD Robin, or anyone out there?

argyrophilic grain disease

It cannot be diagnosed during life as there's no diagnostic criteria for it. It's an age-related dementia.